Drucksache 18 / 20 300 Schriftliche Anfrage 18. Wahlperiode Schriftliche Anfrage des Abgeordneten Marcel Luthe (FDP) vom 18. Juli 2019 (Eingang beim Abgeordnetenhaus am 19. Juli 2019) zum Thema: Medizinische Forschung in Berlin und Antwort vom 07. August 2019 (Eingang beim Abgeordnetenhaus am 09. Aug. 2019) Die Drucksachen des Abgeordnetenhauses sind bei der Kulturbuch-Verlag GmbH zu beziehen. Hausanschrift: Sprosserweg 3, 12351 Berlin-Buckow · Postanschrift: Postfach 47 04 49, 12313 Berlin, Telefon: 6 61 84 84; Telefax: 6 61 78 28. Der Regierende Bürgermeister von Berlin Senatskanzlei - Wissenschaft und Forschung - Herrn Abgeordneten Marcel Luthe (FDP) über den Präsidenten des Abgeordnetenhauses von Berlin über Senatskanzlei - G Sen - A n t w o r t auf die Schriftliche Anfrage Nr. 18/20300 vom 18. Juli 2019 über Medizinische Forschung in Berlin ___________________________________________________________________ Im Namen des Senats von Berlin beantworte ich Ihre Schriftliche Anfrage wie folgt: Die Anfrage betrifft Sachverhalte, die der Senat nicht ohne Beiziehung des Berliner Instituts für Gesundheitsforschung (BIG/BIH) beantworten kann. Es wurde daher um Stellungnahme gebeten. 1. Welche Forschungsprojekte sind seit Gründung des BIH durch das Land Berlin oder den Bund gefördert worden? Zu 1.: Am BIG/BIH werden bzw. wurden seit der Gründung des BIG/BIH bislang 410 wissenschaftliche Projekte gefördert. Die Projekte sind in Anlage 1 aufgeführt. 2. Was genau wurde gefördert, was genau fand/findet im BIH statt: a) Grundlagenforschung b) Anwendungsforschung /Studien mit Patienten, c) Individuelle Medizin? Zu 2.: Das BIG/BIH betreibt keine reine Grundlagenforschung (a), bedient sich aber dieser zur Förderung systemmedizinischer, translational ausgerichteter Forschung. Letztere greift Ansätze und Ideen aus der Grundlagenforschung für die klinische Forschung (b) und spätere Nutzung (c) auf und adressiert Fragestellungen aus dem klinischen Alltag, für die bislang keine hinreichenden Lösungsansätze vorhanden sind. Die Zielstellung ist hierbei, eine möglichst effektive translationale Wertschöpfungskette zu etablieren. Hierzu gehört auch der Aufbau von Strukturen, die für unterschiedliche Schritte der Translation notwendig sind, auch wenn das BIG/BIH selbst keine Krankenversorgung betreibt. - - 2 3. Welche Fachpublikationen zu bzw. aus den von Bund und Land Berlin geförderten Projekten des BIH hat es bisher gegeben? Wo sind diese wann publiziert worden? Zu 3.: Eine Auflistung aller 1559 Fachpublikationen, die es mit Stand Ende Mai 2019 zu bzw. aus den von Bund und Land Berlin geförderten Projekten seit Gründung des BIG/BIH gegeben hat, ist als Anlage 2 beigefügt. 4. In dem Artikel der Morgenpost wird der Regierende Bürgermeister zitiert: Der Beschluss sei zugleich ein Auftrag, Forschungsergebnisse noch schneller an die Krankenbetten zu bringen und maßgeschneiderte Medizin zu entwickeln. „Wir sprechen oft von guten Tagen, aber der heutige ist großartig, vor allem für Patienten in Berlin und in ganz Deutschland“, sagte der Regierende Bürgermeister Müller weiter. Was ist mit „maßgeschneiderter Medizin“ konkret gemeint? Welche „maßgeschneiderte Medizin“ für Patienten wird im BIH praktiziert? Bitte nennen Sie drei Beispiele. Zu 4.: Das BIG/BIH ist selbst nicht in der klinischen Versorgung von Patientinnen und Patienten tätig, daher wird keine „maßgeschneiderte Medizin“ im BIG/BIH praktiziert, sondern wie vom Regierenden Bürgermeister ausgeführt, entwickeln Wissenschaftlerinnen und Wissenschaftler sowie forschende Ärztinnen und Ärzte, basierend auf klinischen Fragestellungen , neue Lösungsansätze und bringen diese in den klinischen Forschungsalltag ein. Mit „maßgeschneiderter Medizin“ ist gemeint, dass, basierend auf genetischen, molekularen und weiteren klinisch relevanten Voraussetzungen einer Patientin oder eines Patienten , die behandelnde Ärztin oder der behandelnde Arzt gemeinsam mit der Patientin oder dem Patienteneine Therapieoption wählt , welche auf die individuellen Ursachen der Erkrankung zugeschnitten ist und für die Patientin oder für den Patienten ein möglichst geringes Risiko von Nebenwirkungen aufweist. Ziel ist es dabei, chronisch fortschreitende Erkrankungen zu verlangsamen und bestenfalls deren Fortschreiten zu verhindern. Die Auswirkungen der zu Grunde liegenden Erkrankungen sollen zudem bestmöglich kontrolliert werden, so dass die Lebensqualität von Patientinnen und Patienten bewahrt oder verbessert werden kann. Das Spektrum schließt neben der gezielten Stratifizierung von Patientinnen und Patienten für bestehende Therapieoptionen auch die Entwicklung von Arzneimitteln für neuartige Therapien ein. Beispiele, bei denen das BIG/BIH maßgeschneiderte Medizin fördert und weiterentwickelt, sind: 1. Transplantationsimmunologie: Im Bereich BIH Regeneration wird eine maßgeschneiderte Therapie zur Verhinderung der Abstoßungsreaktion bei Transplantat- Empfängern entwickelt: Der Empfängerin oder dem Empfänger wird Blut entnommen , die darin enthaltenen regulatorischen T-Zellen werden isoliert und unter GMP (Good manufacturing practice)-Bedingungen expandiert (vervielfältigt) und anschließend der Patientin oder dem Patienten wieder reinfundiert. Diese sorgen dafür, dass das neue Organ nicht abgestoßen wird, obwohl die Patientinnen und Patienten nur einen Bruchteil (etwa ein Zehntel) der immunsuppressiven Medikamente einnehmen, die üblicherweise gegeben werden. Dies hat zur Folge, dass wesentlich weniger Nebenwirkungen auftreten, zum Beispiel Infektionen oder Krebserkrankungen, die unter der massiven Immunsuppression häufig sind. Außer- - - 3 dem war es einer Patientin möglich, ein gesundes eigenes Kind zu bekommen. Unter massiver medikamentöser Therapie ist dies normalerweise nicht möglich. 2. BeLOVE (Berlin Longterm Observation Of Vascular Events)-Studie: Es ist bekannt, dass vaskuläre Erkrankungen (Erkrankungen der Gefäße) häufig nicht alleine auftreten : Nach dem Herzinfarkt folgt der Schlaganfall, eine Niereninsuffizienz birgt die Gefahr einer späteren Herzinsuffizienz etc. Um nun herauszufinden, welche Krankheiten auf welche folgen und warum, und wie man dies verhindern kann, führt das BIG/BIH eine langfristige Studie durch: In dieser wird das individuelle Risiko von Patientinnen und Patienten mit einem akuten vaskulären Ereignis über die Zeit untersucht . Dazu findet kurz nach dem ersten Ereignis und anschließend über zehn Jahre regelmäßig eine intensive Diagnostik der Patientinnen oder Patienten statt. Ziel ist es, maßgeschneiderte Präventionsprogramme für Folgeerkrankungen sowie ggf. neue Therapieoptionen zu entwickeln. 3. Krebs: Krebszellen tragen als Folge der Genveränderungen (Mutationen) häufig veränderte Eiweißmoleküle auf ihrer Oberfläche. Diese können gezielt genutzt werden , um einzelne Krebszellen für das Immunsystem sichtbar zu machen. Das BIG/BIH fördert gemeinsam mit Charité und MDC ein Forschungsprojekt, in dem Wissenschaftlerinnen und Wissenschaftler maßgeschneiderte Immunzellen für Krebspatientinnen und -patienten herstellen können. In klinischen Studien mit betroffenen Patientinnen und Patienten wird demnächst überprüft, ob diese Zellen wie geplant die Veränderung erkennen, die auf den Krebszellen einer individuellen Patientin oder eines individuellen Patienten vorhanden sind, und diese Zellen gezielt abbauen können. 5. Der Regierende Bürgermeister spricht von einer "maßgeschneiderten Medizin" für Patienten. An wen können sich Patienten aktuell wenden, die z. B. aufgrund einer seltenen Erkrankung eine solche maßgeschneiderte Medizin und Forschung konkret dringend benötigen, weil Therapiemöglichkeiten für ihre seltene Erkrankung in Fachabteilungen von Kliniken nicht vorhanden sind? Zu 5.: Zentrale Anlaufstelle für Patientinnen und Patienten mit unklarer Diagnose oder seltenen Erkrankungen ist das Berliner Centrum für seltene Erkrankungen der Charité (BCSE, https://bcse.charite.de). Dieses Centrum und viele Kliniken der Charité arbeiten außerdem mit europäischen Initiativen der „European Reference Networks“ (https://ec.europa.eu/health/ern_de) zusammen. 6. Wie schnell erhalten Patienten mit seltenen Erkrankungen aus Sicht des Regierenden Bürgermeisters voraussichtlich konkrete maßgeschneiderte Hilfe? Zu 6.: Das BIG/BIH hat mitgeteilt, dass bei seltenen Erkrankungen leider keine pauschalen Aussagen möglich sind, da diese von der individuellen Diagnose abhängen. Das BCSE ist darauf spezialisiert, seltene Erkrankungen zu erkennen und zu diagnostizieren, um die oft jahrelange Suche nach einer Diagnose zu beenden. Gelingt es, die Diagnose für eine seltene Erkrankung richtig zu stellen, ergeben sich für die Patientinnen und Patienten oft konkrete Therapieansätze und weitere Hilfsangebote. - - 4 Das BIG/BIH unterstützt die Arbeit des BSCE. Berlin, den 7. August 2019 Der Regierende Bürgermeister von Berlin In Vertretung Christian Gaebler Chef der Senatskanzlei Anlage 1 - Anfrage 18_20300 Welche Forschungsprojekte sind seit Gründung des BIH durch das Land Berlin oder den Bund gefördert worden? Seite 1 von 9 Förderung Leistungsbereich Projekt 1 Bund / Land Berlin CRG 1 Targeting somatic mutations in human cancer by T cell receptor gene therapy 2 Bund / Land Berlin CRG 2 Elucidating the proteostatis network to control Alzheimer’s disease 3 Bund / Land Berlin CRG 3 Towards a better understanding and diagnosis of congenital 4 Bund / Land Berlin CRG 4 From Cancer DiagnOMICS to Precision Medicine: Model Neuroblastoma 5 Bund / Land Berlin TRG Fetal programming of cardiometabolic disease 6 Bund / Land Berlin TRG PRDM16 – a therapeutic target for heart failure 7 Bund / Land Berlin TRG Heterogeneity of immune infiltration in glioblastoma and its implications for molecular diagnostics and personalized treatment decisions 8 Bund / Land Berlin TRG Systems medicine in kidney cancer: towards cancer stem cell-directed therapy 9 Bund / Land Berlin TRG Inflammation-induced skeletal muscle atrophy in critically ill patients: identification of molecular mechanisms and preventive therapies 10 Bund / Land Berlin TRG The role of corollary discharge and the dopamine system in controlling sensory processing: Elucidating a core mechanism in the pathophysiology of psychotic disorders 11 Bund / Land Berlin TRG Systems medicine of BRAF-driven malignancies 12 Bund / Land Berlin CRU OPTICO-ACS 13 Bund / Land Berlin CRU GESPIC-Crohn 14 Bund / Land Berlin CRU BeLOVE 15 Bund / Land Berlin Technologietransfer diagnost-x: Prototyping eines Diagnostikums für Taenia solium in einer klinischen Pilotstudie 16 Bund / Land Berlin Technologietransfer iBikE: Biometrische Unterstützung für SPARK Teams 17 Bund / Land Berlin Technologietransfer Prevention of paclitaxel-induced neuropathy and cognitive impairments with chronic lithium (Li+) pretreatment in mice 18 Bund / Land Berlin Technologietransfer Validation and certification of a pre-tied ready-prepared surgical knot device 19 Bund / Land Berlin Technologietransfer Neuropeptide-based gene therapy for treatment of temporal lobe epilepsy 20 Bund / Land Berlin Technologietransfer MINIMA - Image-based Support of Minimal-Invasive Mitral Valve Repair 21 Bund / Land Berlin Technologietransfer New treatment strategies for rare autoinflammatory diseases - targeting the inflammasome by small molecules 22 Bund / Land Berlin Technologietransfer Topical inflammasome inhibitors – new treatment strategies for inflammatory skin diseases 23 Bund / Land Berlin Technologietransfer MC4R Agonist treatment of patients with monogenic obesity forms 24 Bund / Land Berlin Technologietransfer Molecular imaging of biofilm infections - Validation of FISH control for automated endocarditis diagnostics 25 Bund / Land Berlin Technologietransfer iPSC-based drug discovery for treatment of Leigh syndrome 26 Bund / Land Berlin Technologietransfer Type 3 Deiodinase Inhibitor for Cancer Treatment 27 Bund / Land Berlin Technologietransfer Development and optimization of novel small molecules to treat Metabolic Syndrome. 28 Bund / Land Berlin Technologietransfer TCR gene therapy of CD22-positive B cell malignancies 29 Bund / Land Berlin Technologietransfer AntigIn – Peptide-Based Vaccination Targeting Innate Immune Responses against Viral Infection and Cancer 30 Bund / Land Berlin Technologietransfer Preclinical, GLP-conform validation of primary human muscle stem cells as an ATMP 31 Bund / Land Berlin Technologietransfer Combinatorial treatment of newly developed and repositioned MACC1 and S100A4 inhibitors for metastasis restriction 32 Bund / Land Berlin Technologietransfer A new wearable device for prediction and prevention of congestive events in cardiological patients 33 Bund / Land Berlin Technologietransfer FACTS study: Feasibility and acceptability of a cervical HPV and dysplasia testing and triaging using self-sampling. 34 Bund / Land Berlin Technologietransfer Development, validation and clinical translation of a real-time federated deep learning based platform for predicting postoperative complications during critical care 35 Bund / Land Berlin Technologietransfer Use of circulating cell-free DNA methylation as a diagnostic tool 36 Bund / Land Berlin Technologietransfer Validierung der Osseointegration eines innovativen Dentalimplantates aus dem Hochleistungswerkstoff Polyetheretherketon 37 Bund / Land Berlin Technologietransfer Serum Amyloid A adsorber for dialysis patients 38 Bund / Land Berlin Technologietransfer Frühdiagnose in der rheumatoiden Arthritis durch den anti-MCA3 ELISA Test 39 Bund / Land Berlin Technologietransfer Cancer metastasis restriction using novel molecularly targeted therapies 40 Bund / Land Berlin Technologietransfer Maghämit-Nanopartikel als orales Medikament mit neuartiger Wirksamkeit für die Behandlung der Hyperphosphatämie - Validierung des Wirkmechanismus 41 Bund Technologietransfer OrthoSafety - Fast Track Analyses 42 Bund Technologietransfer Imaging Big Data für die personalisierte Medizin 43 Bund Technologietransfer mTomady - A platform for financial inclusion in healthcare 44 Bund Technologietransfer Computer-assisted diagnostics through machine learning-based histological image 45 Bund Technologietransfer BodyTime - a new diagnostic assay to assess the internal clock 46 Bund Technologietransfer SmartCor - a digital health platform for diagnosis and therapy planning of patients with cardiovascular diseases 47 Bund Technologietransfer Deep Learning for Dental Image Diagnostics 48 Bund Technologietransfer LingPed - an innovative pressure-monitoring insole capable of identifying pathologies througt pedographic analysis 49 Bund / Land Berlin Nachwuchsförderung_JCSP Pharmacological reactivation of the p53 pathway by DS3032b in neuroblastoma 50 Bund / Land Berlin Nachwuchsförderung_JCSP Fertility after chemo- and radiotherapy in childhood and adolescence, FeCt - Multicenter Offspring Study Anlage 1 - Anfrage 18_20300 Welche Forschungsprojekte sind seit Gründung des BIH durch das Land Berlin oder den Bund gefördert worden? Seite 2 von 9 51 Bund / Land Berlin Nachwuchsförderung_JCSP Establishment of a patient-specific syngeneic immune and lymphoma PDX-model for pathogenesis, therapy-prediction and biomarkerdevelopment 52 Bund / Land Berlin Nachwuchsförderung_JCSP The Fractalkine Receptor CX3CR1 and its role in the pathogenesis of choroidal neovascularizations and radiation-induced retinopathy 53 Bund / Land Berlin Nachwuchsförderung_JCSP Mechanisms of Neuronal Dysfunction and Death in Critical Illness-associated Cognitive Impairment 54 Bund / Land Berlin Nachwuchsförderung_JCSP Endothel-spezifische Stat3 Aktivierung durch Transferrinrezeptor-targeted Colivelin zur Regenerationsförderung nach Schlaganfall 55 Bund / Land Berlin Nachwuchsförderung_JCSP Involvement of functional antibodies targeting GPCRs in glomerular disease of native and transplant kidneys 56 Bund / Land Berlin Nachwuchsförderung_JCSP Connectomic surgery in dystonia 57 Bund / Land Berlin Nachwuchsförderung_JCSP Influence of AMD patients’ sera on ARPE-19 cells 58 Bund / Land Berlin Nachwuchsförderung_JCSP Electrical and mechanical dysfunction in atrial cells during diastolic heart failure 59 Bund / Land Berlin Nachwuchsförderung_JCSP Iterative reconstruction in computed tomography – Reducing dose not image quality 60 Bund / Land Berlin Nachwuchsförderung_JCSP Establishment of the most representative “liquid biopsy” method to identify the mutational profile of metastasis from colorectal cancer patients and other gastrointestinal malignancies 61 Bund / Land Berlin Nachwuchsförderung_JCSP Influence of transcranial direct current stimulation on cortical plasticity and on cholinergic cortical activity in Alzheimer‘s disease 62 Bund / Land Berlin Nachwuchsförderung_JCSP Prediction of primary resistance to sunitinib in renal cell carcinoma specimens by miRNA profiles 63 Bund / Land Berlin Nachwuchsförderung_JCSP Identification of biomarkers for acute kidney injury 64 Bund / Land Berlin Nachwuchsförderung_JCSP The regulation and function of Store-operated Calcium Entry (SOCE) in T cell mediated anti-tumor immunity 65 Bund / Land Berlin Nachwuchsförderung_JCSP Inducible neuroplasticity after stroke using neurotransmitter replacement strategies 66 Bund / Land Berlin Nachwuchsförderung_JCSP Caroline meets HANNA – Holistic Analysis of loNgterm-survivors with ovariaN cAncer 67 Bund / Land Berlin Nachwuchsförderung_JCSP The role of neutrophil granulocytes and neutrophil extracellular traps in distinct pathophysiological mechanisms of acute coronary syndrome 68 Bund / Land Berlin Nachwuchsförderung_JCSP High resolution MR-elastography of the hippocampus in patients with Alzheimer’s disease 69 Bund / Land Berlin Nachwuchsförderung_JCSP Complement activation in acute coronary syndrome 70 Bund / Land Berlin Nachwuchsförderung_JCSP Characterisation of intestinal barrierdysfunction in pathogenesis of postoperative ileus in mice 71 Bund / Land Berlin Nachwuchsförderung_JCSP „See, Reach and Treat” – Developing new imaging instruments for diagnostic and minimal-invasive treatments of malignant liver tumors 72 Bund / Land Berlin Nachwuchsförderung_JCSP Investigating the modulation of learning and cognition 73 Bund / Land Berlin Nachwuchsförderung_JCSP Cognitive effects of dopamine and deep brain stimulation in the Ncl. subthalamicus in Parkinson’s disease 74 Bund / Land Berlin Nachwuchsförderung_JCSP Search for markers that can predict efficacy of autologous stem cell therapy in cardiovascular disease 75 Bund / Land Berlin Nachwuchsförderung_JCSP Myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis: Role of the complement system as determinant of antibody pathogenicity and biomarker for clinical phenotype and severity 76 Bund / Land Berlin Nachwuchsförderung_JCSP Antigen-specific activation and adipose-immune interactions in obesity-associated insulin resistance 77 Bund / Land Berlin Nachwuchsförderung_JCSP Routine laboratory parameters and clinical outcome in patients with ischemic stroke with unknown time of symptom onset: a biomarker study 78 Bund / Land Berlin Nachwuchsförderung_JCSP Evaluation and optimisation of endoscopic lung volume reduction therapy in patients with pulmonary emphysema by means of quantitative lung parenchyma analysis 79 Bund / Land Berlin Nachwuchsförderung_JCSP Silent brain infarcts – Incidental finding or risk factor? 80 Bund / Land Berlin Nachwuchsförderung_JCSP Oxidative stress in muscle diseases 81 Bund / Land Berlin Nachwuchsförderung_JCSP Mechanisms of mast cell and T cell interactions during viral infections 82 Bund / Land Berlin Nachwuchsförderung_JCSP Biomarkers and perfusion – Training-induced changes after stroke (BAPTISe) 83 Bund / Land Berlin Nachwuchsförderung_JCSP Immunologic biomarkers and therapeutic targets in rectal cancer 84 Bund / Land Berlin Nachwuchsförderung_JCSP Of heart and mind: A longitudinal neuropsychological evaluation of children with congenital heart disease 85 Bund / Land Berlin Nachwuchsförderung_JCSP The impact of passenger leukocyte migration following solid organ transplantation 86 Bund / Land Berlin Nachwuchsförderung_JCSP Epithelial polarity and intestinal inflammation 87 Bund / Land Berlin Nachwuchsförderung_JCSP Maternity care for migrant women in Berlin – Perceptions of health care professionals and patients 88 Bund / Land Berlin Nachwuchsförderung_JCSP Inhalable nanoparticle formulations targeting the heart. 89 Bund / Land Berlin Nachwuchsförderung_JCSP Prioritization of Exome Data by Image Analysis 90 Bund / Land Berlin Nachwuchsförderung_JCSP Effect of different glioma cell subpopulations on microglia 91 Bund / Land Berlin Nachwuchsförderung_JCSP The role of circular RNAs in neuroblastoma 92 Bund / Land Berlin Nachwuchsförderung_JCSP Identifying druggable targets to suppress PGBD5-driven survival in high-risk neuroblastomas 93 Bund / Land Berlin Nachwuchsförderung_JCSP Early recognition of axial spondyloarthrits in patients with uveitis - establishing and validation of a referral tool 94 Bund / Land Berlin Nachwuchsförderung_JCSP Analyse von inflammationsassoziierten Mutationsprofilen in Kopf-Hals Plattenepithelkarzinomen 95 Bund / Land Berlin Nachwuchsförderung_JCSP Erwartungen und perzeptuelle Entscheidungen bei PatientInnen mit paranoider Schizophrenie und gesunden Kontrollen 96 Bund / Land Berlin Nachwuchsförderung_JCSP Assessment of Abdominal Aortic Aneurysm Rupture Risk with Novel Molecular MRI Probes in an Experimental Mouse Model Anlage 1 - Anfrage 18_20300 Welche Forschungsprojekte sind seit Gründung des BIH durch das Land Berlin oder den Bund gefördert worden? Seite 3 von 9 97 Bund / Land Berlin Nachwuchsförderung_JCSP Distribution and phenotypic characteristics of colonic CD4 T cells in human health and disease 98 Bund / Land Berlin Nachwuchsförderung_JCSP Mineralokortikoidrezeptor-Stimulation und kognitive Funktionen 99 Bund / Land Berlin Nachwuchsförderung_JCSP Preclinical assessment of mesenchymal stromal cell-derived exosomes for therapy of graft-versus-host disease 100 Bund / Land Berlin Nachwuchsförderung_JCSP Genetik angeborener Herzfehler - das hypoplastische Linksherzsyndrom 101 Bund / Land Berlin Nachwuchsförderung_JCSP Activin als neuer Serummarker zur Risikostratifizierung der akuten Pankreatitis. 102 Bund / Land Berlin Nachwuchsförderung_JCSP Funktionelle und therapeutische Evaluation eines bispezifischen, trifunktionalen Antikörpers 103 Bund / Land Berlin Nachwuchsförderung_JCSP Paediatric Telemedicine Diabetes Clinic - A Pioneer Project for Value-based Diabetes Care and Integrated Care Pathways 104 Bund / Land Berlin Nachwuchsförderung_JCSP Disturbed interaction of Purkinje cells and oligodendroglia in the postnalal cerebellum caused by Oxygen 105 Bund / Land Berlin Nachwuchsförderung_JCSP The impact of traumatic brain injury on fracture healing: the role of the hormones leptin, osteocalcin and insulin 106 Bund / Land Berlin Nachwuchsförderung_JCSP Network modulation of motor inhibtion in Parkinson's disease 107 Bund / Land Berlin Nachwuchsförderung_JCSP Association between cholinergic system genetic variants and postoperative delirium and cognitive dysfunction 108 Bund / Land Berlin Nachwuchsförderung_JCSP Illuminating the role of the HBP-ALPK1-TIFA axis - a novel innate immune detector of Gramnegative bacteria 109 Bund / Land Berlin Nachwuchsförderung_JCSP Viral bacterial co-infection in pneumonia – how to better understand the deadly liaison 110 Bund / Land Berlin Nachwuchsförderung_JCSP Characterization of cerebellar function in musician's dystonia patients and its electrical modulation capability 111 Bund / Land Berlin Nachwuchsförderung_JCSP Development of multifunctional polymer-microspheres for the use of catheter-based tumor embolisation. 112 Bund / Land Berlin Nachwuchsförderung_JCSP From Clonal Hematopoiesis to Relapsing Leukemia - Tracing the Roots of AML on Single Cell Level 113 Bund / Land Berlin Nachwuchsförderung_JCSP The role of Calca-derived peptides in experimental arthritis 114 Bund / Land Berlin Nachwuchsförderung_JCSP Targeting Survivin in Neuroblastoma 115 Bund / Land Berlin Nachwuchsförderung_JCSP Decreasing the viability of cyst-lining cells via inactivation of XBP1 as a strategy to treat ADPKD 116 Bund / Land Berlin Nachwuchsförderung_JCSP Calcitonin gene-related peptide (CGRP) in migraine and endometriosis 117 Bund / Land Berlin Nachwuchsförderung_JCSP Analysis of the interdependence between the intestinal microbiota, lymphoma disease and therapeutic immunochemotherapy 118 Bund / Land Berlin Nachwuchsförderung_JCSP The role of dopamine in psychosis-related perceptual aberrations 119 Bund / Land Berlin Nachwuchsförderung_JCSP Immunological and cardiovascular dysbalance in pregnancies conceived through oocyte donation 120 Bund / Land Berlin Nachwuchsförderung_JCSP The Effect of Oxytocin on the Consolidation of Trauma-Associated Memories 121 Bund / Land Berlin Nachwuchsförderung_JCSP Targeting the SUMO pathway as a novel tumor therapy - effects on hematopoiesis and the immune system 122 Bund / Land Berlin Nachwuchsförderung_JCSP Derivation of normal pancreatic duct cells from human primary tissue and their genetic modification using CRISPR/Cas9 123 Bund / Land Berlin Nachwuchsförderung_JCSP Identification of novel molecular genetic causes of proteasome-associated autoinflammatory syndrome 124 Bund / Land Berlin Nachwuchsförderung_JCSP 3-dimensional analysis of blood and lymphatic vasculature in lymphedema using light-sheet imaging based VIPAR approach 125 Bund / Land Berlin Nachwuchsförderung_JCSP Decellularized Human Liver Slices as a Three-Dimensional Platform to Generated In Vitro intrahepatic Cholangiocarcinoma 126 Bund / Land Berlin Nachwuchsförderung_JCSP Validation of a non-invasive, automated perfusion MRI method in stroke patients 127 Bund / Land Berlin Nachwuchsförderung_JCSP Neural Mechanisms of Recovery after Stroke 128 Bund / Land Berlin Nachwuchsförderung_JCSP Evaluation of the validity of new methods for the in vivo assessment of bone quality using intraoperative biopsies. 129 Bund / Land Berlin Nachwuchsförderung_JCSP Improved molecular AML diagnostics-prerequisite for individualized patient management 130 Bund / Land Berlin Nachwuchsförderung_JDCSP Multicentric evaluation of TMS-based risk stratification in brain tumor surgery 131 Bund / Land Berlin Nachwuchsförderung_JDCSP Hybrid modelling - Combining machine learning with physiology-based models in cardiovascular medicine 132 Bund / Land Berlin Nachwuchsförderung_CSP The importance of adipocytokines for the disease pattern of non-ischemic cardiomyopathy 133 Bund / Land Berlin Nachwuchsförderung_CSP The role of EphrinB2-EphB4 signalling for vascular resistance development in malignant glioma 134 Bund / Land Berlin Nachwuchsförderung_CSP Pharmacological and Hormonal Regulation of Intestinal Barrier Function Anlage 1 - Anfrage 18_20300 Welche Forschungsprojekte sind seit Gründung des BIH durch das Land Berlin oder den Bund gefördert worden? Seite 4 von 9 135 Bund / Land Berlin Nachwuchsförderung_CSP Mechanisms of Chemoresistance in Aggressive Lymphomas 136 Bund / Land Berlin Nachwuchsförderung_CSP Deep brain stimulation in epilepsy – a translational approach 137 Bund / Land Berlin Nachwuchsförderung_CSP Evaluation of surgical technique of posterior lamellar keratoplasty and postoperative complications 138 Bund / Land Berlin Nachwuchsförderung_CSP Diffusion Tensor Imaging – new possibilities in Diagnostic Neuroradiology 139 Bund / Land Berlin Nachwuchsförderung_CSP Investigation of nociception during anesthesia using fMRI, EEG and noxious reflexes 140 Bund / Land Berlin Nachwuchsförderung_CSP Pathophysiology and prevention of chemotherapy-induced neuropathy 141 Bund / Land Berlin Nachwuchsförderung_CSP BERLINER Study – The role of circulatory biomarkers alone and in combination with systematic ultrasound to identify the risk of ovarian cancer in pelvic mass patients 142 Bund / Land Berlin Nachwuchsförderung_CSP Retinoic Acid Homeostasis in Major Depression 143 Bund / Land Berlin Nachwuchsförderung_CSP Androgen-dependent regulation of whole body sodium metabolism, blood pressure and cardiovascular function 144 Bund / Land Berlin Nachwuchsförderung_CSP Analysis of epigenetic defects in endocrine diseases 145 Bund / Land Berlin Nachwuchsförderung_CSP Prevention of delirium in critically ill patients+ 146 Bund / Land Berlin Nachwuchsförderung_CSP TLR- and NLR-mediated mucosal endothelial cell activation by probiotics: Role of angiogenesis in inflammatory bowel disease pathogenesis 147 Bund / Land Berlin Nachwuchsförderung_CSP Metabolic Plasticity of Smooth Muscle Cells in Human Vascular disease 148 Bund / Land Berlin Nachwuchsförderung_CSP Molecular characterization of hematopoietic stem and progenitor cell involvement during lymphomagenesis 149 Bund / Land Berlin Nachwuchsförderung_CSP Systemic analysis of genotype-phenotype correlations in GPI-anchor deficiencies 150 Bund / Land Berlin Nachwuchsförderung_CSP Delayed haemolysis following artemisinin therapy of malaria 151 Bund / Land Berlin Nachwuchsförderung_CSP Biomarkers of endothelial function in stroke – the Prospective Cohort with Incident Stroke Study Berlin (PROSCIS-B) 152 Bund / Land Berlin Nachwuchsförderung_CSP Development of high affinity T-cell receptors against Cyclin A1 for the elimination of stem cells in acute myeloid leukemia 153 Bund / Land Berlin Nachwuchsförderung_CSP Regulation of intrinsic anti-inflammatory mediators during renal transplant rejection 154 Bund / Land Berlin Nachwuchsförderung_CSP Mechanisms of neurovascular remodeling and the role of VEGF following stroke 155 Bund / Land Berlin Nachwuchsförderung_CSP Predictors of acute (cardiac) complications after ischemic stroke 156 Bund / Land Berlin Nachwuchsförderung_CSP Theranostic of Prostate Cancer: Radionuclide Therapy and Functional Molecular Hybrid Imaging 157 Bund / Land Berlin Nachwuchsförderung_CSP Altered polarity of intestinal epithelia and its reversal 158 Bund / Land Berlin Nachwuchsförderung_CSP The role of the transcription factor PITX1 in joint development and osteoarthritis 159 Bund / Land Berlin Nachwuchsförderung_CSP Interaction between pathological angiogenesis and retinal neurodegeneration 160 Bund / Land Berlin Nachwuchsförderung_CSP Cellular urinomics – Flow cytometric detection of urinary cell signatures as noninvasive approach to diagnose and investigate renal diseases 161 Bund / Land Berlin Nachwuchsförderung_CSP Molecular characterization of fetal insulin resistance 162 Bund / Land Berlin Nachwuchsförderung_CSP Development of novel treatment strategies for head and neck cancer employing patient-derived xenografts 163 Bund / Land Berlin Nachwuchsförderung_CSP Pathophysiology of the post-operative delirium: Effects of narcotics and inflammatory mediators on neuronal network activity and neurometabolism 164 Bund / Land Berlin Nachwuchsförderung_CSP Cancer stem cells and tumor associated stromal cells in pancreatic cancer 165 Bund / Land Berlin Nachwuchsförderung_CSP Development of prognostic and predictive biomarkers for gastric cancer 166 Bund / Land Berlin Nachwuchsförderung_CSP Granuloma formation, biomarkers and control of tuberculosis disease in children 167 Bund / Land Berlin Nachwuchsförderung_CSP Beyond the margin of local ablation: Perifocal immune response and tumor progression after Image-guided ablative tumor therapies in a VX2 liver tumor model 168 Bund / Land Berlin Nachwuchsförderung_CSP Identification of unstable coronary atherosclerotic plaque using noninvasive 3-Tesla magnetic resonance imaging with an albuminbinding contrast agent 169 Bund / Land Berlin Nachwuchsförderung_CSP iRhom2 in atherosclerosis 170 Bund / Land Berlin Nachwuchsförderung_CSP Development of a microRNA-targeted therapy to regenerate the heart in patients with myocardial infarction: Functional highthroughput screening in human iPSC-derived cardiomyocytes using a microRNA library 171 Bund / Land Berlin Nachwuchsförderung_CSP Plasticity of the human gut microbiota during weight loss and ist consequences in humanized gnotobiotic mice 172 Bund / Land Berlin Nachwuchsförderung_CSP Molecular genetic analysis of CNS lymphoma 173 Bund / Land Berlin Nachwuchsförderung_CSP The neurobiology of delusions – Linking perceptual inference and dopamine 174 Bund / Land Berlin Nachwuchsförderung_CSP Decellularization and recellularization of parenchymal organs 175 Bund / Land Berlin Nachwuchsförderung_CSP Molecular alterations in acute lymphoblastic leukemia as drivers of leukemogenesis and therapeutic targets 176 Bund / Land Berlin Nachwuchsförderung_CSP Functional characterization of the protein TGDS and the pathophysiology of Catel-Manzke syndrome 177 Bund / Land Berlin Nachwuchsförderung_CSP Investigation of functional consequences of clonal hematopoiesis and pharmacological interventions 178 Bund / Land Berlin Nachwuchsförderung_CSP Pathomechanisms and prevention of post-chemotherapy cognitive impairment 179 Bund / Land Berlin Nachwuchsförderung_CSP Neurobiology of chronic depression: Alterations in emotion regulation and influence of psychotherapy 180 Bund / Land Berlin Nachwuchsförderung_CSP Analysis of persistence and efficacy of chimeric antigen receptor (CAR) T cell therapy in solid tumors Anlage 1 - Anfrage 18_20300 Welche Forschungsprojekte sind seit Gründung des BIH durch das Land Berlin oder den Bund gefördert worden? Seite 5 von 9 181 Bund / Land Berlin Nachwuchsförderung_CSP An immune reconstitution and biomarker platform for hematopoietic stem cell transplantation in children 182 Bund / Land Berlin Nachwuchsförderung_CSP Identification and characterization of new microcephaly genes 183 Bund / Land Berlin Nachwuchsförderung_CSP Glycosaminoglycans as targets for non-invasive imaging of unstable atherosclerotic plaques 184 Bund / Land Berlin Nachwuchsförderung_CSP Laser-assisted dermal drug delivery 185 Bund / Land Berlin Nachwuchsförderung_CSP Comparative analysis of tumor heterogeneity in non-small cell lung cancer (NSCLC) by phosphoproteomics and next generation sequencing (NGS) 186 Bund / Land Berlin Nachwuchsförderung_CSP Influence of the complement system on the myofibroblast activation during corneal wound healing 187 Bund / Land Berlin Nachwuchsförderung_CSP Phenotypes, clonal relatedness, and functions of multiple myeloma bone marrow-infiltrating T lymphocytes 188 Bund / Land Berlin Nachwuchsförderung_CSP Influence of endothelial IL6/Stat3 signaling on angiogenesis, ECM remodeling and neuroplasticity after stroke 189 Bund / Land Berlin Nachwuchsförderung_CSP Cellular and molecular characterization of fracture healing in traumatic brain injury 190 Bund / Land Berlin Nachwuchsförderung_CSP NAD+ orchestrates liver regeneration by oxidative stress resistance and stem cell recruitment 191 Bund / Land Berlin Nachwuchsförderung_CSP Adoptive T-cell therapy with enrichment of central memory T-cells in solid organ transplant recipients with CMV infection resistant to antiviral therapy 192 Bund / Land Berlin Nachwuchsförderung_CSP Investigation of the role of neonatal oxidative stress in neonatal brain development and genesis of ADHD like symptoms 193 Bund / Land Berlin Nachwuchsförderung_CSP Hypothermia and neuroprotection: A role for cold-shock proteins? 194 Bund / Land Berlin Nachwuchsförderung_CSP Prevention of neuromuscular organ failure in critically ill patients 195 Bund / Land Berlin Nachwuchsförderung_CSP Inhibition of the CXCL2/CXCR2 signaling pathway in GBM as therapeutic option 196 Bund / Land Berlin Nachwuchsförderung_CSP The role of CD39+ Foxp3+ regulatory T-cells in cholangiocarcinoma progression 197 Bund / Land Berlin Nachwuchsförderung_CSP Imaging genetics and epigenetics in alcohol use disorder 198 Bund / Land Berlin Nachwuchsförderung_CSP Targeting intravital protein interactions in neuronal energy metabolism of stroke 199 Bund / Land Berlin Nachwuchsförderung_CSP Defatting of steatotic liver grafts by ex vivo machine perfusion with DNP 200 Bund / Land Berlin Nachwuchsförderung_CSP Epigenetic changes and repair of the DNA breaks in skeletal muscle in critical illness myopathy 201 Bund / Land Berlin Nachwuchsförderung_CSP Mechanisms of gastric stem cell control upon infection and carcinogenesis 202 Bund / Land Berlin Nachwuchsförderung_CSP Evaluation and integration of molecular assays to address clinical problems in breast cancer 203 Bund / Land Berlin Nachwuchsförderung_CSP The heart as an endocrine organ: Chromogranin B and the inositol-1,4,5-trisphosphate receptor in excitation-secretion coupling in cardiomyocytes 204 Bund / Land Berlin Nachwuchsförderung_CSP Einflussfaktoren auf das Ansprechen auf Antidepressiva bei PatientInnen mit türkischem Migrationshintergrund 205 Bund / Land Berlin Nachwuchsförderung_CSP Role of ENTPD3 in acute and chronic liver disease 206 Bund / Land Berlin Nachwuchsförderung_CSP Transfusionsassoziierte Auswirkungen auf die Entwicklung eines Ventilations-induzierten Lungenschadens 207 Bund / Land Berlin Nachwuchsförderung_CSP Probing and manipulating neuronal circuits in obesity 208 Bund / Land Berlin Nachwuchsförderung_CSP Big Data Analytics in Healthcare – Medical Data Science to Improve Patient Safety during Intensive Care 209 Bund / Land Berlin Nachwuchsförderung_CSP Dissection and functional validation of recurrent driver gene mutations in primary mediastinal B-cell lymphoma 210 Bund / Land Berlin Nachwuchsförderung_CSP Prostatakarzinom Large-Scale Radiomics- Analyse der Prostatakarzinom-Bildgebung zur nichtinvasiven Risikostratifizierung 211 Bund / Land Berlin Nachwuchsförderung_CSP Molecular mechanisms of tumor-immune cell interaction in glioblastoma 212 Bund / Land Berlin Nachwuchsförderung_CSP Assessing cell type-specific gene expression profiles in healthy and diseased kidney tissues using single-cell RNA-seq 213 Bund / Land Berlin Nachwuchsförderung_CSP Circulating blood biomarkers for diagnostic, progostic and therapeutic utilisation in cancer patients 214 Bund / Land Berlin Nachwuchsförderung_CSP Femtosecond laser assisted versus manual descemetorhexis 215 Bund / Land Berlin Nachwuchsförderung_CSP Alternative Osteosynthesematerialien für die Kieferrekonstruktion 216 Bund / Land Berlin Nachwuchsförderung_CSP Role and regulation of Nox4 in retinal cells during diabetes 217 Bund / Land Berlin Nachwuchsförderung_CSP Phosphoryliertes alpha-Synuclein der Haut als Biomarker neurodegenerativer Parkinson Syndrome 218 Bund / Land Berlin Nachwuchsförderung_CSP Fertility in patients with chronic anaemic diseases, FeCt-Haematology 219 Bund / Land Berlin Nachwuchsförderung_CSP Novel Treatment and Diagnostic Approaches utilizing the Role of Dendritic Cells in Immune Responsivness 220 Bund / Land Berlin Nachwuchsförderung_CSP Biomarker development for adult hemophagocytic lymphohistiocytosis in intensive care units 221 Bund / Land Berlin Nachwuchsförderung_CSP Functional brain changes and pain reduction in IBD patients via tDCS 222 Bund / Land Berlin Nachwuchsförderung_CSP Personalised management of acute ischemic stroke patients – prehospital triage strategies and imaging biomarkers. 223 Bund / Land Berlin Nachwuchsförderung_CSP Phenomics & Genomics of Clozapine Pharmacotherapy 224 Bund / Land Berlin Nachwuchsförderung_CSP Influence of the peripheral CYP 2C19 enzyme activity on depression in two distinct ethnic groups 225 Bund / Land Berlin Nachwuchsförderung_CSP Deep brain stimulation as novel treatment for rapid-onset dystonia parkinsonism 226 Bund / Land Berlin Nachwuchsförderung_CSP Putative role for bacterial metabolites in protection from hypertensive organ damage Anlage 1 - Anfrage 18_20300 Welche Forschungsprojekte sind seit Gründung des BIH durch das Land Berlin oder den Bund gefördert worden? Seite 6 von 9 227 Bund / Land Berlin Nachwuchsförderung_CSP Mobilization of donor immunological memory and its fate after allogeneic hematopoietic stem cell transplantation 228 Bund / Land Berlin Nachwuchsförderung_CSP Molecular PET-MR- Imaging for detection and characterization of vulnerable atherosclerotic plaques in coronary arteries 229 Bund / Land Berlin Nachwuchsförderung_CSP Functional characterization,pharmacological modulation and clinical correlation of rare CFTRmutations in human epithelia 230 Bund / Land Berlin Nachwuchsförderung_CSP Mechanical Atrial Dysfunction in Heart Failure 231 Bund / Land Berlin Nachwuchsförderung_CSP Homeostatic control after stroke – effects of challenge tests on metabolic and cerebral biomarkers 232 Bund / Land Berlin Nachwuchsförderung_CSP Establishment of a Clinical Research Unit for LEADER Transition from prenatal diagnosis to healthy and wealthy adulthood 233 Bund / Land Berlin Nachwuchsförderung_CSP Immunological and morphological signatures in non-infectious chorioretinitis 234 Bund / Land Berlin Nachwuchsförderung_CSP B-mode ultrasound as a novel noninvasive imaging biomarker for the functional assessment of the afferent visual pathway 235 Bund / Land Berlin Nachwuchsförderung_CSP Role of MIF in human acute peritonitis 236 Bund / Land Berlin Nachwuchsförderung_CSP Molecular characterization of spinal paraganglioma 237 Bund / Land Berlin Nachwuchsförderung_CSP Significance of the transcription factor TAZ in lymphocytes for Treg- TH17 balance and Ang II-induced end-organ damage 238 Bund / Land Berlin Nachwuchsförderung_CSP The role of mesenteric fat in intestinal inflammation 239 Bund / Land Berlin Nachwuchsförderung_CSP The role of neural network rewiring and ageing during motor recovery after stroke 240 Bund / Land Berlin Nachwuchsförderung_CSP Characterization of the tumor and its surrounding microenvironment during treatment to improve future cancer therapies 241 Bund / Land Berlin Nachwuchsförderung_CSP Cytokine-armed oncolytic vaccinia virus for pancreatic cancer therapy 242 Bund / Land Berlin Nachwuchsförderung_CSP Predicting cognitive deficits and response to non-invasive brain stimulation in patients with schizophrenia 243 Bund / Land Berlin Nachwuchsförderung_CSP Predictors of cognitive decline after deep brain stimulation in Parkinson's disease 244 Bund / Land Berlin Nachwuchsförderung_CSP Role of mast cells in herpes simplex virus infection 245 Bund / Land Berlin Nachwuchsförderung_CSP Comprehensive analysis of the relation between Epstein-Barr virus infection and intrathecal Ig production in MS 246 Bund / Land Berlin Nachwuchsförderung_CSP Mechanisms of sudden cardiac death, arrhythmias and cardiac contractile dysfunction in HFpEF 247 Bund / Land Berlin Nachwuchsförderung_CSP Development of a translational precision oncology program for head and neck cancers 248 Bund / Land Berlin Nachwuchsförderung_CSP The Impact of Donor Derived Microparticles Following Solid Organ Transplantation 249 Bund / Land Berlin Nachwuchsförderung_CSP Prevalence of Small Fibre Neuropathy in Systemic Sclerosis 250 Bund / Land Berlin Nachwuchsförderung_CSP The influence of virtual and structural lesions of frontal cortex on perceptual decisions 251 Bund / Land Berlin Nachwuchsförderung_CSP MR-based evaluation of aortic aneurysm rupture risk with albumin-binding and novel ADAMTS-4-specific molecular probes 252 Bund / Land Berlin Nachwuchsförderung_CSP Inhalable nanoparticle formulations targeting the heart. 253 Bund / Land Berlin Nachwuchsförderung_CSP Evaluating circular RNAs in neuroblastoma as potential therapeutic targets 254 Bund / Land Berlin Nachwuchsförderung_CSP Forward genetic screening for analysis and therapeutic targeting of BCL6-associated lymphoma 255 Bund / Land Berlin Nachwuchsförderung_CSP Estrogen- and Progesterone-induced improvement of fear extinction in healthy women 256 Bund / Land Berlin Nachwuchsförderung_CSP Targeting Inflamed Endothelium with Smart Exosomes for Cardioprotection 257 Bund / Land Berlin Nachwuchsförderung_CSP The functional characterization of anti-mGluR5 antibodies in Ophelia syndrome and its link to Hodgkin lymphoma 258 Bund / Land Berlin Nachwuchsförderung_CSP Investigation of hematoma growth in intracerebral hemorrhage in a translational approach 259 Bund / Land Berlin Nachwuchsförderung_CSP Epigenetic regulation of plasma cell differentiation in Systemic Lupus Erythematosus 260 Bund / Land Berlin Nachwuchsförderung_CSP Role of spleen tyrosine kinase (Syk) in pulmonary arterial hypertension (PAH) 261 Bund / Land Berlin Nachwuchsförderung_Pilot grants FlurinoCyte – Urine Flow Cytometry as non-invasive biomarker for renal diseases 262 Bund / Land Berlin Nachwuchsförderung_Pilot grants A Mobile Health Wallet for Madagascar 263 Bund / Land Berlin Nachwuchsförderung_Pilot grants Validation and certification of a pre-tied ready-prepared surgical knot device 264 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Aktivierung und Modulation endogener zentralnervöser Reparatur-mechanismen bei chronischer Inflammation des zentralen Nervensystems 265 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Funktionsanalyse von Immunzellen mittels Fluoreszenzlebensdauer-Cytometry 266 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Die Bedeutung des Plasmamembrantransporters mINDY in der Leberregeneration 267 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Identifizierung Pathogenese-relevanter Kandidatengene in lymphatischen Neoplasien durch CRISPR/Cas9-basiertes knockout-Screening 268 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Interaction of microglia with tumor stem cells 269 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Therapeutic potential of the ISG15-system in inflammatory cardiomyopathy 270 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Entwicklung neuer ZNS-Läsionsmodelle im in vivo Modell 271 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien EphrinB2-EphB4 pathway as a therapeutic target in spinal metastasis formation 272 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Funktionelle Charakterisierung der Antikörper vermittelter Protease-aktivierten Rezeptor-1 (PAR-1) Aktivierung 273 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Zellzykluskontrolle β-herpesviraler Kinasen 274 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Untersuchung von Resolutionsdefiziten nach Rückenmarks-verletzung in Abhängigkeit von der anatomischen Veletzungslokalisation sowie der spinalen Verletzungshöhe: tierexperimentelle Untersuchungen am Versuchstier Ratte 275 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Molekulare Identifizierung der klonalen Hämatopiese und deren Dynamik in Patienten mit myelotoxischer Chemotherapie 276 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Evaluierung des Wilms‘ Tumor Proteins WT1 als potenzielles Ziel zur Behandlung des Neuroblastoms Anlage 1 - Anfrage 18_20300 Welche Forschungsprojekte sind seit Gründung des BIH durch das Land Berlin oder den Bund gefördert worden? Seite 7 von 9 277 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Die Rolle der Stammzellfraktion und des Notchsignalwegs im Intrahepatischen und Extrahepatischen Cholangiokarzinoms 278 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Identifikation der Zielstrukturen von Anti-Tumor TZellen bei paraneoplastischer Kleinhirndegeneration 279 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Genetische Faktoren zur Regulation der Knochemasse 280 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Zfp580 als Substrat endogener Neuroprotektion: Untersuchungen von Expression und post- translationaler Modifikationen in Mausmodellen 281 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Analyse der Überlebensnische von Plasmazellen im Gehirn mit molekularer Mulitplex-System Histologie 282 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Untersuchung und Vergleich struktureller funktioneller Veränderungen des afferenten visuellen Systems bei Erkrankungen des Neuromyelitis optica Spektrums 283 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Charakterisierung der Immunantwort gegen Maser-Impfvirus 284 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Rolle von gp130 in Muskelatrophie und im Impfvirus Muskelproteom durch Inflammation 285 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Immunogenicity of allogeneic cardiac-derived adherent proliferating (CardAP)-cells from the atrial auricule 286 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Analysis of the 17β-Estradiol effect on collagen I and III expression in human cardiac fibroblasts 287 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Renal and Extrarenal Effects of Vasopressin in the Regulation of the Water and Electrolyte Homeostasis 288 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Identification of predictors for a response to anti-TNFα-treatment in IBD patients 289 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Evaluation of Role of VEGF in Oxaliplatin-Induced Sinusoidal Obstruction Syndrome - In-Vivo and In-Vitro Studies 290 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien ​Phenotypical and functional Assay of Human Terminally Differentiated Effector T Cells (Temra) in Human​ 291 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Epigenetic control of endothelial phenotype and atherosclerosis in response to atherogenic blood flow 292 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien The effects of WT1 on gene expression and alternative pre-mRNA splicing in embryonic kidneys and renal cancer 293 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Prioritization of Exome Data by Image Analysis 294 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Evaluating the Influence of PD1-Inhibition on the CAR-T-Cell Therapy Efficiency in Neuroblastoma. 295 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Characterization of Incidence, Imaging Pattern and Pathobiology of Radiation Necrosis in High-Grade Gliomas 296 Bund / Land Berlin Nachwuchsförderung_BIH-TRENAL Promotionsstipendien mTOR complexes in renal tubular epithelial cell homeostasis 297 Bund / Land Berlin Nachwuchsförderung_BIH-TRENAL Promotionsstipendien Proof of specific T-cells in blood and urine samples of patients with active ANCA-associated vasculitis 298 Bund / Land Berlin Nachwuchsförderung_BIH-TRENAL Promotionsstipendien Untersuchung von DAAM1 in normalem Nebennierenkortex und Nebennierenrindentumoren 299 Bund / Land Berlin Nachwuchsförderung_BIH-TRENAL Promotionsstipendien Oxalat als Trigger der IL-16 Freisetzung aus Entzündungszellen 300 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Fibroblasten-mediierte Vorhofdysfunktion bei diastolischer Herzinsuffizienz und hypertensiver Herzkrankheit. 301 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Konstruktion eines endokrinen Neo-Pankreas 302 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Verbesserte Fraktuheilung nach Schädelhirntrauma - die Rolle der verletzungsabhängigen Immunantwort 303 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Die Rolle extrazellulärer RNA und DNA bei Inflammation nach experimenteller Subarachnoidalblutung. 304 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Klinische Charakteristika und molekulare Ursachen von segmentalen progeroiden Erkrankungen. 305 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Proteolyse in Immunzellen bei entzündlichen Herzmuskelerkrankungen 306 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Strukturelle und funktionelle Veränderungen der Retina als Diagnoseund Verlaufsparameter chronischer Neuroinflammation 307 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Tiefgehende Phänotypisierung cytometrischer Daten 308 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Auswirkungen von Calcium-Kanal-Blockern auf durch oxidativen Stress induzierte, mitochondriale Veränderungen 309 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien CRISPR/Cas9-vermittelte Genveränderung von T Zellen– Ein Ansatz zur Verbesserung von T-Zelltherapien 310 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Lokalisation des Schilddrüsenhormontransporters MCT8 im humanen Gehirn und Therapieentwicklung für MCT8-Defizienz 311 Bund / Land Berlin Nachwuchsförderung_BIH-TRENAL Promotionsstipendien Oxalat als Auslöser für eine IL-16 Ausschüttung 312 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Untersuchungen zu bekannten Krankheitsgenen und neuen Kandidatengenen bei monogenetischen Formen der art. Hypertonie 313 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Charakterisierung der Stammzelldynamik im Mausantrum im Kontext der Helicobacter pylori-Infektion und des p53 Knockouts 314 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Klassifizierung sinunasaler Tumore anhand ihres DNA-Methylierungsprofils 315 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Evaluation einer Kombination aus bispezifischem trifunktionalem Antikörper und Checkpoint-Inhibition im Neuroblastom 316 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien 3D-Chromatinstruktur der akuten myeloischen Leukämie mit komplexen genetischen (genomischen) Aberrationen 317 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Präklin. Evaluation von Panobinostat in Kombination mit zielgerichteten Therapeutika und konv. Chemoth. im Neuroblastom 318 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Synergismus bei Genom- und Metabolismus stabilisierender Antitumortherapie in der Brustkrebszelllinie MCF-7 319 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Die Charakterisierung von Ionenkanälen und Rezeptoren in Mikroglia im Verlauf der Alzheimer-Demenz Anlage 1 - Anfrage 18_20300 Welche Forschungsprojekte sind seit Gründung des BIH durch das Land Berlin oder den Bund gefördert worden? Seite 8 von 9 320 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Die Rolle von Immunglobulinen der Klasse A und E bei chronischer spontaner Urtikaria. 321 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Phänotypische Charakterisierung onkogen-inaktiver Krebszellen 322 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Aufzeigen der Mechanismen hinter Chemoresistenzen in Rhabdomyosarkomen 323 Bund / Land Berlin Nachwuchsförderung_BIH Promotionsstipendien Untersuchung des Einflusses von KDM1A auf Neuroblastom-spezifische CAR-T-Zelltherapie 324 Bund / Land Berlin Nachwuchsförderung_BIH-TRENAL Promotionsstipendien Modulation der Cyclosporin-A vermittelten Nephrotoxizität durch PHD-Inhibitoren 325 Bund / Land Berlin Nachwuchsförderung_BIH-TRENAL Promotionsstipendien Oxalat als Auslöser einer Veränderung der Monozyten-Subtypen und IL-16 Ausschüttung 326 Bund / Land Berlin Nachwuchsförderung_Translational Postdoc Identification of therapeutically relevant key factors in vascular calcification 327 Bund / Land Berlin Nachwuchsförderung_Translational Postdoc ARHGAP36-mediated inhibition of Protein Kinase A in skeletal muscle development, regeneration and disease 328 Bund / Land Berlin Nachwuchsförderung_Translational PhD Identifying the mechanisms of antidepressant drug action in mice lacking brain serotonin 329 Bund / Land Berlin Nachwuchsförderung_Translational PhD Targeting alternative translational initiation of oncogenes in cancer cells 330 Bund / Land Berlin Nachwuchsförderung_Translational PhD Investigation of the energy expenditure of human iPSC-derived basal ganglia neurons from patients with Leigh Syndrome 331 Bund / Land Berlin Nachwuchsförderung_Translational PhD The role of human microglia for glioma progression 332 Bund / Land Berlin Nachwuchsförderung_Translational PhD Impact of energy metabolism on bone regeneration 333 Bund / Land Berlin Nachwuchsförderung_Translational PhD Functional characterization of osteoactivin/Gpnmb in myocardial infarction 334 Bund / Land Berlin Nachwuchsförderung_Translational PhD Modulation of neonatal olfactory cortex spontaneous synchronized activity in the GLUK2 KO model of mental retardation 335 Bund / Land Berlin Nachwuchsförderung_Translational PhD Regulation of pro- and anti-inflammatory mechanisms mediated by fatty acid metabolites in metabolic liver damage – a role for omega-3 fatty acids in prevention? 336 Bund / Land Berlin Nachwuchsförderung_Translational PhD RNA-edited glycine receptor as marker and therapeutic target in intractable epilepsy 337 Bund / Land Berlin Nachwuchsförderung_Translational PhD Decoding the metabolic program of deregulated MYCN expression in neuroblastoma 338 Bund / Land Berlin Nachwuchsförderung_Translational PhD Novel gene therapeutic approaches to osteopetrosis 339 Bund / Land Berlin Nachwuchsförderung_Translational PhD Dissection of GvHD and tumor rejection by selective inhibition of NFAT-activation and gut-migration of adoptively transferred T cells 340 Bund / Land Berlin Nachwuchsförderung_Translational PhD Investigating mechanisms of microglia-mediated neuronal damage processes in Multiple Sclerosis pathophysiology 341 Bund / Land Berlin Nachwuchsförderung_Translational PhD Study of novel molecular defects in human pancreas dysfunction 342 Bund / Land Berlin Nachwuchsförderung_Translational PhD Modulation of muscle afferent mechanotransduction to treat painful muscle pathologies 343 Bund / Land Berlin Nachwuchsförderung_Translational PhD Placental and cardiovascular maladaption during preeclampsia as a risk factor for future cardiovascular disease 344 Bund / Land Berlin Nachwuchsförderung_Translational PhD Identification of interacting molecular Partners and their Role in human Physiology and Pathophysiology of Epithelial Transport 345 Bund / Land Berlin Nachwuchsförderung_Translational PhD Epigenetic disturbances contribute to the etiology of Preeclampsia 346 Bund / Land Berlin Nachwuchsförderung_Translational PhD Dissecting the cellular and molecular mechanisms of leukemia cell migration and localization to and within the testis in childhood ALL 347 Bund / Land Berlin QUEST Replikationsstudien 348 Bund / Land Berlin QUEST eLN 349 Bund / Land Berlin QUEST MERIT 350 Bund / Land Berlin QUEST Dimensions 351 Bund / Land Berlin Programme/Plattformen Establish a BIH Repository of hiPSC Reference Cell Lines 352 Bund / Land Berlin Programme/Plattformen Single cell RNA sequencing (scRNAseq) pipeline for in depth characterization of organoids 353 Bund / Land Berlin Programme/Plattformen Workshop “How to address authorative agencies in the field of ATMPs and orphan drug designation” 354 Bund / Land Berlin Programme/Plattformen Engineering genetic biosensors to improve quality control and monitoring of iPSC derived organoids in cancer, neuroscience, and cardiovascular research. 355 Bund / Land Berlin Programme/Plattformen Ex vivo modeling of human glioblastoma using multicellular organoids 356 Bund / Land Berlin Programme/Plattformen Bone/bone-marrow on a chip 357 Bund / Land Berlin Programme/Plattformen Pathogenic effects of mHTT 358 Bund / Land Berlin Programme/Plattformen Assessing therapeutic options for high-risk neuroblastomas in patient- derived models 359 Bund / Land Berlin Programme/Plattformen National and international requirements to introduce ATMPs into clinical use 360 Bund / Land Berlin Programme/Plattformen Humanized immunocompromised animal models 361 Bund / Land Berlin Programme/Plattformen Efficient diagnosis of MUC1 mutations in autosomal dominant tubulointerstitial kidney disease by single molecule real time sequencing 362 Bund / Land Berlin Programme/Plattformen Analysis of post-translational modification (PTM)-driven pathways in neuroblastoma to define signatures for risk classification and therapy selection 363 Bund / Land Berlin Programme/Plattformen Parallel single-cell circular DNA and linear RNA sequencing in neuroblastoma tumor cells 364 Bund / Land Berlin Programme/Plattformen SWGS4SCQC – Shallow whole genome sequencing for stem cell quality control 365 Bund / Land Berlin Programme/Plattformen Redefine subcategories of inflammatory bowel disease 366 Bund / Land Berlin Programme/Plattformen Dilated cardiomyopathy 367 Bund / Land Berlin Programme/Plattformen Proof-of-principle to implement clinical mass spectrometry for precision medicine 368 Bund / Land Berlin Programme/Plattformen Effects of CFTR Modulator Therapy on the Proteome, Metabolome and Microbiome in Patients with Cystic Fibrosis 369 Bund / Land Berlin Programme/Plattformen Single Cell RNA Sequencing 370 Bund / Land Berlin Programme/Plattformen In-depth tissue phenotyping by imaging mass cytometry 371 Bund / Land Berlin Programme/Plattformen Deep Neuroretina (OCTA/AI) 372 Bund / Land Berlin Programme/Plattformen Integrated morpho-molecular precision oncology Anlage 1 - Anfrage 18_20300 Welche Forschungsprojekte sind seit Gründung des BIH durch das Land Berlin oder den Bund gefördert worden? Seite 9 von 9 373 Bund / Land Berlin Programme/Plattformen Test lab for HL7 FHIR and CDA data from wearables and smartphone apps 374 Bund / Land Berlin Programme/Plattformen Implementation of a central ID and consent management 375 Bund / Land Berlin Programme/Plattformen Empowering the Charité Health Data Platform for broad applications in digital medicine across clinical sectors 376 Bund / Land Berlin Programme/Plattformen Verbesserung von HIV-1-Cure Strategien unter Hilfe von single cell-seq 377 Bund / Land Berlin Programme/Plattformen Bornavirus infection in limbic encephalitis 378 Bund / Land Berlin Programme/Plattformen GMP-grade retrovirus NY-ESO 1 for anti cancer gene therapy 379 Bund / Land Berlin Programme/Plattformen Erweitertes Mapping regulatorischer Sequenzen in humanen Immun- und Knochenzellen 380 Bund / Land Berlin Programme/Plattformen KryoMatrix 381 Bund / Land Berlin Programme/Plattformen Hybrid-Detektoren für Konfokales&2P-Mikroskop 382 Bund / Land Berlin Programme/Plattformen Diagnostic test system for the detection of CRISPR-associated nuclease 383 Bund / Land Berlin Programme/Plattformen Vorbereitung autoCard-Studie nach Behördenanforderungen 384 Bund / Land Berlin Programme/Plattformen KI-basierte Stimmdiagnostik 385 Bund / Land Berlin Programme/Plattformen Standardisierte Medikamentenverordnung in den elektronischen Krankenakten auf Intensivstationen 386 Bund / Land Berlin Programme/Plattformen EINFÜHRUNG EINER STANDARDISIERTEN KODIERUNG FÜR LABORDATEN 387 Bund / Land Berlin Programme/Plattformen Sepsis-Alert 388 Bund / Land Berlin Programme/Plattformen Explainable AI-Modell zur Diagnostik von Prostatakarzinomen im MRT 389 Bund / Land Berlin Programme/Plattformen Digital Diabetes Clinic (DDC) – Ein Pionierprojekt für Patient-Centered Design und Value Based Healthcare 390 Bund / Land Berlin Programme/Plattformen Deep functional proteogenomic systems analysis of non-small-cell lung cancer 391 Bund / Land Berlin Programme/Plattformen Strukturierte elektronische Erfassung und Optimierung der Medikation 392 Bund / Land Berlin Programme/Plattformen Safe-Data-Projekt SUMATRA 393 Bund / Land Berlin Programme/Plattformen HPC4Clinic 394 Bund / Land Berlin Programme/Plattformen Stammzellbasierte Generierung von individualiserten in vitro Modellen für hereditäre Nierenerkrankungen 395 Bund / Land Berlin Programme/Plattformen Using RNA-profiling to investigate brain-heart interaction 396 Bund / Land Berlin Programme/Plattformen Metabolic alterations associated with osteosarcoma progression and metastasis 397 Bund / Land Berlin Programme/Plattformen Early Detection of Lung Disease in Children with Cystic Fibrosis (Detect CF) 398 Bund / Land Berlin Programme/Plattformen Effect of a probiotic on blood pressure in low-to-moderate risk grade 1 hypertension - a randomized trial (HYPRO) 399 Bund / Land Berlin Programme/Plattformen CLP-mediated remyelination in multiple sclerosis 400 Bund / Land Berlin Programme/Plattformen International Conference on Health Data Science 401 Bund / Land Berlin Programme/Plattformen A user guide for statistical power and sample size calculations 402 Bund / Land Berlin Programme/Plattformen Statistische Fehldenkweisen in der medizinischen Forschung 403 Bund / Land Berlin Programme/Plattformen Early childhood risk factors for blood pressure increase and potential mechanisms 404 Bund / Land Berlin Programme/Plattformen PROKOGE - Genetic screening of MRI probands with high PSA to estimate the necessity of diagnostic prostate biopsy. 405 Bund / Land Berlin Programme/Plattformen Digitale Phänotypisierung 406 Bund / Land Berlin Programme/Plattformen Übersetzung der Human Phenotype Ontology 407 Bund / Land Berlin Programme/Plattformen BELOVE Plasmaproteomics durch Massenspektrometrie 408 Bund / Land Berlin Programme/Plattformen LESS 409 Bund / Land Berlin Programme/Plattformen Multi-omics single cell profiling of colorectal cancer 410 Bund / Land Berlin Programme/Plattformen Strukturelle Effekte von CSP Programmen Anlage 2 - Anfrage 18_20300 Welche Fachpublikationen zu bzw. aus den von Bund und Land Berlin geförderten Projekten des BIH hat es bisher gegeben? Wo sind diese wann publiziert worden? Stand Mai 2019 Seite 1 von 190 a Dzaye, O. D., F. Hu, K. Derkow, V. Haage, P. Euskirchen, C. Harms, S. Lehnardt, M. Synowitz, S. A. Wolf, and H. Kettenmann. "Glioma Stem Cells but Not Bulk Glioma Cells Upregulate Il-6 Secretion in Microglia/Brain Macrophages Via Toll-Like Receptor 4 Signaling." J Neuropathol Exp Neurol 75, no. 5 (May 2016): 429-40. http://dx.doi.org/10.1093/jnen/nlw016. Aarnio, K., J. Rodriguez-Pardo, B. Siegerink, J. Hardt, J. Broman, L. Tulkki, E. Haapaniemi, M. Kaste, T. Tatlisumak, and J. Putaala. "Return to Work after Ischemic Stroke in Young Adults: A Registry-Based Follow-up Study." Neurology 91, no. 20 (Nov 13 2018): e1909-e17. http://dx.doi.org/10.1212/WNL.0000000000006510. Abbasi, A. A., K. Blaesius, H. Hu, Z. Latif, S. Picker-Minh, M. N. Khan, S. Farooq, M. A. Khan, and A. M. Kaindl. "Identification of a Novel Homozygous Trappc9 Gene Mutation Causing Non-Syndromic Intellectual Disability, Speech Disorder, and Secondary Microcephaly." Am J Med Genet B Neuropsychiatr Genet (Oct 14 2017). http://dx.doi.org/10.1002/ajmg.b.32602. Abrusan, G., S. R. Yant, A. Szilagyi, J. A. Marsh, L. Mates, Z. Izsvak, O. Barabas, and Z. Ivics. "Structural Determinants of Sleeping Beauty Transposase Activity." Mol Ther 24, no. 8 (Aug 2016): 1369-77. http://dx.doi.org/10.1038/mt.2016.110. Acker, G., M. Czabanka, P. Schmiedek, and P. Vajkoczy. "Pregnancy and Delivery in Moyamoya Vasculopathy: Experience of a Single European Institution." Neurosurg Rev 41, no. 2 (Apr 2018): 615-19. http://dx.doi.org/10.1007/s10143-017-0901-5. Acker, G., L. Fekonja, and P. Vajkoczy. "Surgical Management of Moyamoya Disease." Stroke 49, no. 2 (Feb 2018): 476-82. http://dx.doi.org/10.1161/STROKEAHA.117.018563. Acker, G., S. Goerdes, P. Schmiedek, M. Czabanka, and P. Vajkoczy. "Characterization of Clinical and Radiological Features of Quasi-Moyamoya Disease among European Caucasians Including Surgical Treatment and Outcome." Cerebrovasc Dis 42, no. 5-6 (Aug 2016): 464-75. http://dx.doi.org/10.1159/000448812. Acker, G., C. Lange, I. Schatka, A. Pfeifer, M. A. Czabanka, P. Vajkoczy, and R. Buchert. "Brain Perfusion Imaging under Acetazolamide Challenge for Detection of Impaired Cerebrovascular Reserve Capacity: Positive Findings with (15)O-Water Pet in Patients with Negative (99m)Tc-Hmpao Spect Findings." J Nucl Med 59, no. 2 (Feb 2018): 294-98. http://dx.doi.org/10.2967/jnumed.117.195818. Acker, G., S. K. Piper, A. L. Datwyler, T. Broggini, I. Kremenetskaia, M. Nieminen- Kelha, J. Lips, U. Harms, S. Mueller, G. Lattig-Tunnemann, E. Trachsel, A. Palumbo, D. Neri, J. Klohs, M. Endres, P. Vajkoczy, C. Harms, and M. Czabanka. "Targeting the Extradomain a of Fibronectin Allows Identification of Vascular Resistance to Antiangiogenic Therapy in Experimental Glioma." Oncotarget 9, no. 45 (Jun 12 2018): 27760-72. http://dx.doi.org/10.18632/oncotarget.25570. Acker, G., N. Schlinkmann, L. Fekonja, L. Grunwald, J. Hardt, M. Czabanka, and P. Vajkoczy. "Wound Healing Complications after Revascularization for Moyamoya Anlage 2 - Anfrage 18_20300 Welche Fachpublikationen zu bzw. aus den von Bund und Land Berlin geförderten Projekten des BIH hat es bisher gegeben? Wo sind diese wann publiziert worden? Stand Mai 2019 Seite 2 von 190 Vasculopathy with Reference to Different Skin Incisions." Neurosurg Focus 46, no. 2 (Feb 1 2019): E12. http://dx.doi.org/10.3171/2018.11.FOCUS18512. Acker, G., N. Schlinkmann, S. K. Piper, J. Onken, P. Vajkoczy, and T. Picht. "Stereoscopic Versus Monoscopic Viewing of Aneurysms: Experience of a Single Institution with a Novel Stereoscopic Viewing System." World Neurosurg (Jul 31 2018). http://dx.doi.org/10.1016/j.wneu.2018.07.189. Ackermann, S., M. Cartolano, B. Hero, A. Welte, Y. Kahlert, A. Roderwieser, C. Bartenhagen, E. Walter, J. Gecht, L. Kerschke, R. Volland, R. Menon, J. M. Heuckmann, M. Gartlgruber, S. Hartlieb, K. O. Henrich, K. Okonechnikov, J. Altmuller, P. Nurnberg, S. Lefever, B. de Wilde, F. Sand, F. Ikram, C. Rosswog, J. Fischer, J. Theissen, F. Hertwig, A. D. Singhi, T. Simon, W. Vogel, S. Perner, B. Krug, M. Schmidt, S. Rahmann, V. Achter, U. Lang, C. Vokuhl, M. Ortmann, R. Buttner, A. Eggert, F. Speleman, R. J. O'Sullivan, R. K. Thomas, F. Berthold, J. Vandesompele, A. Schramm, F. Westermann, J. H. Schulte, M. Peifer, and M. Fischer. "A Mechanistic Classification of Clinical Phenotypes in Neuroblastoma." Science 362, no. 6419 (Dec 7 2018): 1165-70. http://dx.doi.org/10.1126/science.aat6768. Adam, I., D. L. Dewi, J. Mooiweer, A. Sadik, S. R. Mohapatra, B. Berdel, M. Keil, J. K. Sonner, K. Thedieck, A. J. Rose, M. Platten, I. Heiland, S. Trump, and C. A. Opitz. "Upregulation of Tryptophanyl-Trna Synthethase Adapts Human Cancer Cells to Nutritional Stress Caused by Tryptophan Degradation." Oncoimmunology 7, no. 12 (Sep 2018): e1486353. http://dx.doi.org/10.1080/2162402X.2018.1486353. Adegbola, A., L. Musante, B. Callewaert, P. Maciel, H. Hu, B. Isidor, S. Picker-Minh, C. Le Caignec, B. Delle Chiaie, O. Vanakker, B. Menten, A. Dheedene, N. Bockaert, F. Roelens, K. Decaestecker, J. Silva, G. Soares, F. Lopes, H. Najmabadi, K. Kahrizi, G. F. Cox, S. P. Angus, J. F. Staropoli, U. Fischer, V. Suckow, O. Bartsch, A. Chess, H. H. Ropers, T. F. Wienker, C. Hubner, A. M. Kaindl, and V. M. Kalscheuer. "Redefining the Med13l Syndrome." Eur J Hum Genet 23, no. 10 (Oct 2015): 1308- 17. http://dx.doi.org/10.1038/ejhg.2015.26. Adolf, A., A. Rohrbeck, A. Munster-Wandowski, M. Johansson, H. G. Kuhn, M. A. Kopp, B. Brommer, J. M. Schwab, I. Just, G. Ahnert-Hilger, and M. Holtje. "Release of Astroglial Vimentin by Extracellular Vesicles: Modulation of Binding and Internalization of C3 Transferase in Astrocytes and Neurons." Glia (Nov 28 2018). http://dx.doi.org/10.1002/glia.23566. Aerts, H., M. Schirner, B. Jeurissen, D. Van Roost, E. Achten, P. Ritter, and D. Marinazzo. "Modeling Brain Dynamics in Brain Tumor Patients Using the Virtual Brain." eNeuro 5, no. 3 (May 2018). http://dx.doi.org/10.1523/ENEURO.0083- 18.2018. Aghlmandi, S., N. Scharer, D. Heg, L. Raber, M. Zwahlen, B. Gencer, D. Nanchen, D. Carballo, S. Carballo, P. Juni, A. von Eckardstein, U. Landmesser, N. Rodondi, F. Mach, S. Windecker, C. M. Matter, T. F. Luscher, and R. Klingenberg. "Thrombus Aspiration in Acute Coronary Syndromes: Prevalence, Procedural Success, Change Anlage 2 - Anfrage 18_20300 Welche Fachpublikationen zu bzw. aus den von Bund und Land Berlin geförderten Projekten des BIH hat es bisher gegeben? Wo sind diese wann publiziert worden? Stand Mai 2019 Seite 3 von 190 in Serial Troponin T Levels and Clinical Outcomes in a Contemporary Swiss Cohort." Eur Heart J Acute Cardiovasc Care (Apr 1 2017): 2048872617706480. http://dx.doi.org/10.1177/2048872617706480. Ahmad, R., B. Kumar, Z. Chen, X. Chen, D. Muller, S. M. Lele, M. K. Washington, S. K. Batra, P. Dhawan, and A. B. Singh. "Loss of Claudin-3 Expression Induces Il6/Gp130/Stat3 Signaling to Promote Colon Cancer Malignancy by Hyperactivating Wnt/Beta-Catenin Signaling." Oncogene (Aug 07 2017). http://dx.doi.org/10.1038/onc.2017.259. Akhmedov, A., F. Montecucco, V. Braunersreuther, G. G. Camici, P. Jakob, M. F. Reiner, M. Glanzmann, F. Burger, F. Paneni, K. Galan, G. Pelli, N. Vuilleumier, A. Belin, J. P. Vallee, F. Mach, and T. F. Luscher. "Genetic Deletion of the Adaptor Protein P66shc Increases Susceptibility to Short-Term Ischaemic Myocardial Injury Via Intracellular Salvage Pathways." Eur Heart J 36, no. 8 (Feb 21 2015): 516-26a. http://dx.doi.org/10.1093/eurheartj/ehu400. Al Masri, S., R. Reincke, H. Huenigen, O. Gemeinhardt, K. C. Richardson, and J. Plendl. "Computed Tomography Study of the Fetal Development of the Dairy Cow Stomach Complex." J Dairy Sci (Dec 13 2017). http://dx.doi.org/10.3168/jds.2017- 13508. Albers, A. E., X. Qian, A. M. Kaufmann, and A. Coordes. "Meta Analysis: Hpv and P16 Pattern Determines Survival in Patients with Hnscc and Identifies Potential New Biologic Subtype." Sci Rep 7, no. 1 (Dec 1 2017): 16715. http://dx.doi.org/10.1038/s41598-017-16918-w. Al-Bughaili, M., T. M. Neuhann, R. Flottmann, S. Mundlos, M. Spielmann, U. Kornak, and B. Fischer-Zirnsak. "A De Novo 1q23.3-Q24.2 Deletion Combined with a Gorab Missense Mutation Causes a Distinctive Phenotype with Cutis Laxa." J Hum Genet 62, no. 2 (Feb 2017): 325-28. http://dx.doi.org/10.1038/jhg.2016.111. Aleksandrova, K., D. Mozaffarian, and T. Pischon. "Addressing the Perfect Storm: Biomarkers in Obesity and Pathophysiology of Cardiometabolic Risk." Clin Chem (Nov 14 2017). http://dx.doi.org/10.1373/clinchem.2017.275172. Alenina, N. and M. Bader. "Ace2 in Brain Physiology and Pathophysiology: Evidence from Transgenic Animal Models." Neurochem Res (Nov 15 2018). http://dx.doi.org/10.1007/s11064-018-2679-4. Alesutan, I., M. Feger, R. Tuffaha, T. Castor, K. Musculus, S. S. Buehling, C. L. Heine, O. M. Kuro, B. Pieske, K. Schmidt, A. Tomaschitz, W. Maerz, S. Pilz, A. Meinitzer, J. Voelkl, and F. Lang. "Augmentation of Phosphate-Induced Osteo- /Chondrogenic Transformation of Vascular Smooth Muscle Cells by Homoarginine." Cardiovasc Res 110, no. 3 (Jun 01 2016): 408-18. http://dx.doi.org/10.1093/cvr/cvw062. Alesutan, I., R. Tuffaha, T. Auer, M. Feger, B. Pieske, F. Lang, and J. Voelkl. "Inhibition of Osteo/Chondrogenic Transformation of Vascular Smooth Muscle Cells Anlage 2 - Anfrage 18_20300 Welche Fachpublikationen zu bzw. aus den von Bund und Land Berlin geförderten Projekten des BIH hat es bisher gegeben? Wo sind diese wann publiziert worden? Stand Mai 2019 Seite 4 von 190 by Mgcl2 Via Calcium-Sensing Receptor." J Hypertens 35, no. 3 (Mar 2017): 523-32. http://dx.doi.org/10.1097/HJH.0000000000001202. Alesutan, I., J. Voelkl, M. Feger, D. V. Kratschmar, T. Castor, S. Mia, M. Sacherer, R. Viereck, O. Borst, C. Leibrock, M. Gawaz, O. M. Kuro, S. Pilz, A. Tomaschitz, A. Odermatt, B. Pieske, C. A. Wagner, and F. Lang. "Involvement of Vascular Aldosterone Synthase in Phosphate-Induced Osteogenic Transformation of Vascular Smooth Muscle Cells." Sci Rep 7, no. 1 (May 17 2017): 2059. http://dx.doi.org/10.1038/s41598-017-01882-2. Al-Hakim, S., A. Schaumann, J. Schneider, M. Schulz, and U. W. Thomale. "Experience in Shunt Management on Revision Free Survival in Infants with Myelomeningocele." Childs Nerv Syst (Mar 26 2018). http://dx.doi.org/10.1007/s00381-018-3781-2. Al-Maghout, T., L. Pelzl, I. Sahu, B. Sukkar, Z. Hosseinzadeh, R. Gutti, S. Laufer, J. Voelkl, B. Pieske, M. Gawaz, and F. Lang. "P38 Kinase, Sgk1 and Nf-Kappab Dependent up-Regulation of Na+/Ca2+ Exchanger Expression and Activity Following Tgfss1 Treatment of Megakaryocytes." Cell Physiol Biochem 42, no. 6 (Aug 15 2017): 2169-81. http://dx.doi.org/10.1159/000479992. Alogna, A., M. Manninger, M. Schwarzl, B. Zirngast, P. Steendijk, J. Verderber, D. Zweiker, H. Maechler, B. M. Pieske, and H. Post. "Inotropic Effects of Experimental Hyperthermia and Hypothermia on Left Ventricular Function in Pigs-Comparison with Dobutamine." Crit Care Med 44, no. 3 (Mar 2016): e158-67. http://dx.doi.org/10.1097/CCM.0000000000001358. Alogna, A., M. Schwarzl, M. Manninger, N. Hamdani, B. Zirngast, B. Kloth, P. Steendijk, J. Verderber, D. Zweiker, D. Westermann, S. Blankenberg, H. Maechler, C. Tschope, W. A. Linke, G. Marsche, B. M. Pieske, and H. Post. "Acute Stimulation of the Soluble Guanylate Cyclase Does Not Impact on Left Ventricular Capacitance in Normal and Hypertrophied Porcine Hearts in Vivo." Am J Physiol Heart Circ Physiol 315, no. 3 (Sep 1 2018): H669-H80. http://dx.doi.org/10.1152/ajpheart.00510.2017. Althoff, K., A. Beckers, E. Bell, M. Nortmeyer, T. Thor, A. Sprussel, S. Lindner, K. De Preter, A. Florin, L. C. Heukamp, L. Klein-Hitpass, K. Astrahantseff, C. Kumps, F. Speleman, A. Eggert, F. Westermann, A. Schramm, and J. H. Schulte. "A Cre- Conditional Mycn-Driven Neuroblastoma Mouse Model as an Improved Tool for Preclinical Studies." Oncogene 34, no. 26 (Jun 2015): 3357-68. http://dx.doi.org/10.1038/onc.2014.269. Althoff, K., J. H. Schulte, and A. Schramm. "Towards Diagnostic Application of Non- Coding Rnas in Neuroblastoma." 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